Mechanism Of Action Of Domperidone The DA2-receptor antagonist domperidone antagonizes the inhibitory effect of dopamine, resulting in stimulation of gastric muscle contraction. This provides a mechanism for the gastrokinetic effect of domperidone. Therapeutic Indications Of Motilium Tablets Domperidone is used in adults to treat the following symptoms: nausea (feeling sick) and vomiting (being sick), a heavy stomach or bloating, a sensation of discomfort in the stomach area, or when stomach contents flow back into the gullet, as with belching and heartburn.