Acne spot care that's never been so fun! What it is: Spot treatment to care for your blemishes overnight. Perfect for: Blemish, Acne, Deep unsurfaced pimples Why It's Special: . Target Spot Care Formulated with Calamine and Vitamin B12, this drying lotion cares for the acne spots while clearing your skin. . Blend Formulated to Soothe and Heal Calamine, Zinc Oxide, Salicylic Acid, and Centella works to cool and calm the area of concern. . Pimple Prevention If you feel a big spot coming under your skin, spot treats to prevent future breakouts.