Alpha-lipoic Acid 600 - 1800 mg/day in 3 divided doses according to severity. 600 mg/ day for a maintenance therapy. Doses must be taken on an empty stomach, 1 hour before or 2 hours after meals Indicated and Recommended as a pathogenic treatment for neuropathy through it's: 1-Vaso-protective effect. 2-Neuro-protective. 3-Anti-oxidant effect 4-Blocks the destructive pathway of hyperglycemic damage